Key clinical point: Contralateral prophylactic mastectomy (CPM) did not offer any survival benefit to patients with triple-negative breast cancer (TNBC) irrespective of the presence of BRCA mutations.
Major finding: The 5-year overall survival did not significantly improve with vs without CPM in the entire population of patients with TNBC ( P = .05) and in the subgroups of patients with ( P = .35) and without ( P = .12) BRCA mutations.
Study details: Findings are from a multi- institutional database study including 796 patients with TNBC, of which 15.5% of patients underwent CPM.
Disclosures: This study did not receive any funding. The authors declared no conflicts of interest.
Source: Fasano GA et al. Survival outcomes in women with unilateral, triple-negative, breast cancer correlated with contralateral prophylactic mastectomy. Ann Surg Oncol. 2023 (Jan 21). Doi: 10.1245/s10434-022-13056-0