Key clinical point: Older patients with ductal carcinoma in situ (DCIS) of the breast or hormone receptor-positive (HR+)/human epidermal growth factor receptor 2-positive (HER2+ or ERBB2+) early-stage breast cancer (BC) who underwent mastectomy vs lumpectomy experienced a significantly greater decline in frailty status.
Major finding: Women who underwent mastectomy vs lumpectomy were more likely to experience worse frailty (adjusted odds ratio 1.31; 95% CI 1.23-1.39).
Study details: Findings are from a cohort study including 31,084 women aged ≥65 years with DCIS (n = 9962) or HR+/ ERBB2+ (n = 21,122) stage I BC, of which 22.6% and 77.4% of patients underwent mastectomy and lumpectomy, respectively.
Disclosures: This study was funded by the Brigham and Women’s Hospital Department of Surgery, Utah. Some authors declared serving as advisors, on the board of directors, and on steering committees, or receiving grants, personal fees, honoraria, or funding from various sources.
Source: Minami CA et al. Association of surgery with frailty status in older women with early-stage breast cancer. JAMA Surg. 2023 (Mar 15). Doi: 10.1001/jamasurg.2022.8146