Key clinical point: Preterm birth was positively associated with the risk for incident premenopausal breast cancer (BC) in women aged <55 years who experienced preeclampsia or gestational hypertension.
Major finding: Overall, a history of preterm birth was not associated with the risk for premenopausal BC (hazard ratio [HR] 1.02; 95% CI 0.92-1.14). However, it was positively associated with the risk for premenopausal BC in women who had preeclampsia or gestational hypertension (HR 1.52; 95% CI 1.06-2.18). Preeclampsia on the other hand was inversely associated with premenopausal BC risk (HR 0.86; 95% CI 0.75-0.99).
Study details: Findings are from an analysis of six cohort studies including 184,866 premenopausal women aged <55 years, of which 3096 women were diagnosed with premenopausal BC.
Disclosures: This study was supported by the US National Institutes of Health and other sources. The authors declared no conflicts of interest.
Source: Nichols HB et al. Hypertensive conditions of pregnancy, preterm birth, and premenopausal breast cancer risk: A premenopausal breast cancer collaborative group analysis. Breast Cancer Res Treat. 2023 (Apr 5). Doi: 10.1007/s10549-023-06903-5