Nevertheless, given the frequency of use of these medications in pregnant women in the first trimester, this study suggests that caution might be exercised in situations in which casual or indiscriminate use of these medications in early pregnancy could be avoided.
Dr. Chambers is associate professor of pediatrics and family and preventive medicine at the University of California, San Diego. She is director of the California Teratogen Information Service and Clinical Research Program. Dr. Chambers is a past president of the Organization of Teratology Information Specialists and past president of the Teratology Society. She said she had no relevant financial disclosures.