The occurrence of rhabdomyosarcoma arising in a GCMN could be explained by the pluripotential nature of undifferentiated neural crest cells. These cells likely maintain the ability for rhabdomyoblastic differentiation. This mesenchymal derivative originates from the cranial or cephalic portion of the neural crest. The term ectomesenchyme applies to the potential of the ectoderm to give rise to mesenchymal tissue and indeed may be the pathway by which a rhabdomyosarcoma arises.5
Conclusion
We report a fifth case of rhabdomyosarcoma arising in a GCMN. Our patient underwent surgical resection of the rhabdyomyosarcoma at age 2 months, with subsequent chemotherapy consisting of actinomycin D and vincristine. She has tolerated outpatient chemotherapy well, with no gross evidence of local recurrence, and will complete 12 months of therapy for her low-risk rhabdomyosarcoma.