Lymphomatoid Drug Reaction Secondary to Methylphenidate Hydrochloride

Lymphomatoid drug reactions are relatively rare, with no gender, race, or age predilection. The condition generally may be divided into 2 broad categories with some overlap: (1) drug-induced pseudolymphoma and (2) anticonvulsant-induced pseudolymphoma syndrome, marked by the triad of papular to nodular skin lesions, fever, and lymphadenopathy. While a vast array of pharmacologic agents has been linked to lymphomatoid drug reactions, our case represents the first reported incidence of methylphenidate hydrochloride—a ubiquitously prescribed medication for attention deficit hyperactivity disorder—causing a pseudolymphoma.