Pediatric Dermatology

Vesiculopustular Eruption Associated With Transient Myeloproliferative Disorder

Author and Disclosure Information

Transient myeloproliferative disorder (TMD) is a hematologic abnormality usually associated with Down syndrome that may present with a skin eruption in addition to typical systemic findings. We report a case of a patient with TMD and a vesiculopustular eruption without the phenotypic characteristics of Down syndrome who was found to have mosaic trisomy 21. Mutations of the globin transcription factor 1 gene, GATA1, are associated with both TMD and acute megakaryocytic leukemia. Transient myeloproliferative disorder typically presents with pancytopenia, hepatosplenomegaly, and immature circulating white blood cells, and affects approximately 10% of neonates with Down syndrome. These abnormalities rapidly regress within the first few months of life. However, 20% to 30% of neonates with Down syndrome and TMD later develop leukemia. The tumor antigen PRAME (preferentially expressed antigen in melanoma) may serve as a marker for leukemic transformation. We report an illustrative case to alert clinicians about this uncommon cause of vesiculopustular eruption in a neonate without the phenotypic characteristics of Down syndrome and review the clinical findings and laboratory studies that aid in accurate diagnosis.

Recommended Reading

10 New Substances Added to Patch Test Tray
MDedge Dermatology
Cryolipolysis on Track to Become First Cool Way to Remove Cellulite
MDedge Dermatology
Coal Tar Solution Tops Calcipotriol Cream for Psoriasis
MDedge Dermatology
Denial
MDedge Dermatology
Staining for P75 Helps Make Desmoplastic Melanoma Dx
MDedge Dermatology
Mycosis Fungoides Appears Early in Black Women
MDedge Dermatology
New Primary Cutaneous B-Cell Lymphoma Guidelines Highlight Differential Diagnosis
MDedge Dermatology
Certified Dermatology EMRs to Debut in 2010
MDedge Dermatology
Teens Pay for Outdoor Summer Jobs as Adults
MDedge Dermatology
Oral Cavity SCC in Young Adults Is on the 'Surge'
MDedge Dermatology