Efficacy and Tolerability of Fixed-Combination Acne Treatment in Adolescents

Acne is common among adolescents and can be difficult to manage. Providing an effective treatment method that offers an early onset of action and a favorable tolerability profile may lead to improved adherence, increased satisfaction, and improved clinical outcomes in this patient population. A post hoc analysis was conducted of 1755 adolescents (age range, 12 to

Significantly superior reductions in inflammatory, noninflammatory, and total lesion counts were observed in the CP 1.2%–BPO 2.5% gel group versus the other 3 groups (P≤.002 for all week 12 pairwise comparisons). At week 12, treatment success with CP 1.2%–BPO 2.5% gel was statistically superior to CP 1.2% (P=.004), BPO 2.5% (P=.031), and vehicle (P<.001 participants observed improvement with cp gel treatment as early week of reporting their skin was clear almost or showed marked improvement. clindamycin phosphate associated a low incidence treatment-related adverse events and favorable cutaneous tolerability profile.>