Delayed Hypersensitivity Reaction to Restylane^&#174

This case report documents the first known case of a delayed hypersensitivity reaction to Restylane^®. The patient experienced typical symptoms of a delayed hypersensitivity reaction to soft tissue augmentation materials. Serum testing was negative, and biopsy of skin testing in the arm demonstrated a typical delayed hypersensitivity reaction.
This case report discusses treatment with hyaluronidase and other modalities in the first demonstrated hypersensitivity reaction to a hyaluronic acid injectable material.