Extensive Erythema Multiforme With an Unusual Delineated Presentation: A Case Report

Erythema multiforme majus (EMM) is a hypersensitivity reaction usually secondary to medications, viruses, or other infections. Its presentation is fairly typical with a symmetrical distribution of vesicles, bullae, or targetoid lesions on the upper body, arms, legs, palms, feet, and oral mucosa. The authors present a case of EMM with a very unusual clinical presentation evolving over time into a unique, almost dermatomal distribution. Typical therapies were not initially helpful and intravenous immunoglobulin antibody had to be administered.