Hypertrophic Scars and Keloids, Part 2: Newer and Investigational Therapies

Hypertrophic scars (HTSs) and keloids are benign proliferative scar tissues that represent a dysregulation in the wound healing process. These lesions not only result in disfigurement but also can cause symptoms such as pain and pruritus. Although treatments for HTSs and keloids have been extensively studied, even the most successfully proven methods can be ineffective for some patients. To treat patients refractory to more conventional therapies, newer therapies constantly are being investigated for these recalcitrant lesions. Some of these modalities employ new uses for old drugs, such as angiotensin-converting enzyme inhibitors and verapamil, while others, such as gene therapy, represent cutting-edge treatments. In part 2 of this series we highlight various new and investigational therapies; although they are not yet available for use, these therapies demonstrate exciting and promising potential for successfully managing HTSs and keloids.