Laresse is not approved for use in the United States.
▸ ArteFill (Artes Medical Inc.). This FDA-approved product is a successor of Artecoll, a formulation of polymethyl methacrylate (PMMA) spheres suspended in collagen that was found to cause a high incidence of lumps when injected into the lips and delayed granulomatous reactions in the face. "Now the product's PMMA crystals have been polished, and it's being marketed as ArteFill," Dr. Braun said. "Many of the complications I saw came out in year 7, so be very careful injecting this. It remains to be seen if this product is safer than Artecoll."
▸ DermaLive and DermaDeep (DermaTech). This permanent filler, a combination of polyethyl methacrylate and hyaluronic acid, was withdrawn from France in 2003 and later from Canada because nodules and granulomas were reported years after injection.
"I ask patients on my medical history sheet if they've had this filler, because if you inject other things in a DermaLive recipient, you can activate a foreign body reaction," Dr. Braun said.
Dr. Braun disclosed that he has received honoraria from Medicis, which markets Restylane, and Allergan, which markets Juvéderm. He owns no stock in either company.
"Be very cautious,"when using Evolence in the lips, said Dr. Martin Braun. Nodule formationas shown in the patient above 15 months after injectioncan occur. Courtesy Dr. Martin Braun