A 9-year-old girl was admitted with fever, fatigue, cough, eye and mouth pain, and scattered cutaneous pustules that rapidly progressed to painful erosions and bullae involving the conjunctivae, genitals, lips, and body. The patient was hospitalized 18 months prior to presentation with similar symptoms; she was diagnosed with Stevens-Johnson syndrome (SJS) secondary to Mycoplasma pneumoniae infection, which was confirmed by polymerase chain reaction analysis. Clinicians should recognize the possibility of recurrence of SJS to provide appropriate evaluation and therapeutic intervention.