Melanoma was an important topic at multiple sessions of the 73rd Annual Meeting of the American Academy of Dermatology (AAD) in San Francisco, California. Dr. Susan M. Swetter reviews the AAD and National Comprehensive Cancer Network recommendations for biopsy of pigmented suspicious lesions. She also discusses when sentinel lymph node biopsies are recommended and factors that would indicate a patient needs a sentinel lymph node biopsy. Dr. Swetter also outlines surgical margins for melanoma and emphasizes that these are clinical margins taken at the time of surgery, not histologic margins. She concludes with a review of the melanoma subtype lentigo maligna.