Key clinical point: Hepatocellular carcinoma patients with lung or bone metastasis have a significantly worse prognosis than patients without these metastases.
Major finding: In a multivariate analysis, independent predictors of poor overall survival and cancer-specific survival in HCC patients included age 52 years and older, male sex, low degree of tumor differentiation, N1 stage, lack of primary surgery or chemoradiotherapy, tumor size greater than 6 cm, and multiple organ metastasis.
Study details: The data come from a retrospective review of 3,126 adults with distant metastasis of hepatocellular carcinoma from 2010 to 2015; patients were grouped based on metastatic sites.
Disclosures: The study was funded by the Natural Science Foundation of Jiangsu Province. The researchers had no financial conflicts to disclose.
Source: Zhan H et al. Front Oncol. 2021 May 10. doi: 10.3389/fonc.2021.652768.