Key clinical point: Approximately half of the studies (16) in a systematic review showed no association between androgen deprivation therapy and reduced cognitive function in prostate cancer patients; however, 11 of the 31 studies showed a negative effect on cognitive functioning.
Major finding: A total of 18 studies used a prospective design to assess the impact of androgen deprivation therapy on cognitive function, totaling 968 individuals. Of these, 9 studies showed no significant effect of ADT on cognitive function.
Study details: The data come from a systematic review of 31 studies published up to February 2020.
Disclosures: The study received no outside funding. The researchers had no financial conflicts to disclose.
Source: Andela CD et al. Int J Urol. 2021 Jun 14. doi: 10.1111/iju.14596.