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Testosterone Accumulation in PCa Cells Enhanced by Facilitated Diffusion
Key clinical point: Facilitated testosterone uptake by tumor cells supports a cell nonautonomous mechanism for testosterone signaling in castration-resistant prostate cancers (CRPC).
Major finding: Testosterone uptake followed a concentration gradient but unlike in passive diffusion, was saturable and temperature-dependent, suggesting facilitated transport.
Study details: In vitro3 H-testosterone uptake assays were performed in androgen-dependent LNCaP and androgen and AR-independent PC3 cells, and CRPC metastases for expression of AKR1C3 was analyzed.
Citation:
Kaipainen A, et al. Prostate. 2019 Aug 2. doi: 10.1002/pros.23874.