Key clinical point: Gastric ulcer (GU) is positively associated with the risk for gastric cancer, whereas duodenal ulcer (DU) shows no association with gastric cancer risk.
Major finding: GU was associated with an increased risk for gastric cancer (odds ratio [OR] 3.04; 95% CI 2.07-4.49). No association between DU and gastric cancer risk was observed (OR 1.03; 95% CI 0.77-1.39).
Study details: This pooled analysis of 11 case-control studies in the Stomach Cancer Pooling Consortium investigated the association between peptic ulcer disease and gastric cancer among 4106 patients with gastric cancer and 6922 control individuals.
Disclosures: This study was sponsored by Associazione Italiana per la Ricerca sul Cancro, Italy, and others. The authors declared no conflicts of interest.
Source: Paragomi P et al. The association between peptic ulcer disease and gastric cancer: Results from the Stomach Cancer Pooling (StoP) project consortium. Cancers (Basel). 2022;14(19):4905 (Oct 7). Doi: 10.3390/cancers14194905