Clinical Edge | MDedge Hematology and Oncology

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

This Week's Must Reads

Younger adults present with more advanced esophageal adenocarcinoma,

PDAC: Tumor reduction after neoadjuvant therapy may predict postsurgical survival,

Mortality risks rise with age, infections, but not inhibitor status in persons with non-severe hemophilia A,

‘Impressive’ local control with MRI-guided brachytherapy in cervical cancer,

U.S. mothers underestimate role breastfeeding plays in curbing breast cancer,

Renal Cell Carcinoma

Study shows no link between race and mortality in clear cell RCC,

Four factors may predict better survival with cabozantinib in mRCC,

Read more in Renal Cell Carcinoma

Hodgkin Lymphoma

Childhood Hodgkin survivors have neurocognitive impairment,

Survey quantifies COVID-19’s impact on oncology,

Read more in Hodgkin Lymphoma

Business of Medicine

Chinese American families suffer discrimination related to COVID-19,

Men occupy most leadership roles in medicine,

Read more in Business of Medicine

Prostate Cancer

Single-Fraction Radiation Misses Mark for Spinal Compression Relief,

Read more in Prostate Cancer

Angiosarcoma

Survey quantifies COVID-19’s impact on oncology,

Read more in Angiosarcoma

Ewing's Sarcoma

Similar outcomes for extraskeletal and skeletal Ewing sarcomas in adults, Lynch A et al. Surgical Oncology 2018: 27; 373-379. https://doi.org/10.1016/j.suronc.2018.05.016

Read more in Ewing's Sarcoma

Mixed Topics

Phase 1 study: Beta-blocker may improve melanoma treatment response,

REALITY trial supports restrictive transfusion in anemic MI,

Read more in Mixed Topics

Metastatic Breast Cancer

Should CTCs guide treatment choice in HR+, HER2– breast cancer?,

Survey quantifies COVID-19’s impact on oncology,

Read more in Metastatic Breast Cancer

Thrombosis

DOACs look safe in elective endoscopic procedures,

Lusutrombopag found safe, effective for severe thrombocytopenia in patients with hepatocellular carcinoma,

Read more in Thrombosis

Transfusion Medicine

Hemochromatosis variants may confer 10-fold higher risk of liver cancer,

INR fails to predict bleeding in patients with cirrhosis,

Read more in Transfusion Medicine

Translational Research

Will TP53-mutated AML respond to immunotherapy?,

TP53 double hit predicts aggressive myeloma,

Read more in Translational Research

T Cell Lymphomas

Phase 1 study shows feasibility, safety, efficacy of STAR T cells for ALL,

Duvelisib response rate encouraging in phase 2 PRIMO trial of patients with r/r PTCL,

Read more in T Cell Lymphomas

GI Oncology

Younger adults present with more advanced esophageal adenocarcinoma,

PDAC: Tumor reduction after neoadjuvant therapy may predict postsurgical survival,

Read more in GI Oncology

Immuno-oncology

Lenvatinib/pembrolizumab has good activity in advanced RCC, other solid tumors,

Dual immunotherapy goes the distance in MSI-H colorectal cancer,

Read more in Immuno-oncology

GIST

Liquid biopsy aids assessment in advanced imatinib-resistant GIST, George S et al. ASCO 2018. Abstract 11511.

Rapid therapy changes fall short for metastatic GIST, Serrano-Garcia C et al. ASCO 2018, Abstract 11510.

Read more in GIST

Transplant

Caregiver burden of outpatient ASCT for multiple myeloma comparable with inpatient transplant,

Allogeneic transplant leads to durable remissions in T-cell lymphomas,

Read more in Transplant

All Specialties