Explore a Clinical Edge Topic | MDedge Hematology and Oncology

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Explore a Topic

GIST

Liquid biopsy aids assessment in advanced imatinib-resistant GIST, George S et al. ASCO 2018. Abstract 11511.

Rapid therapy changes fall short for metastatic GIST, Serrano-Garcia C et al. ASCO 2018, Abstract 11510.

Read more in GIST

Prostate Cancer

Single-Fraction Radiation Misses Mark for Spinal Compression Relief,

Read more in Prostate Cancer

Mixed Topics

Phase 1 study: Beta-blocker may improve melanoma treatment response,

REALITY trial supports restrictive transfusion in anemic MI,

Read more in Mixed Topics

Immuno-oncology

Lenvatinib/pembrolizumab has good activity in advanced RCC, other solid tumors,

Dual immunotherapy goes the distance in MSI-H colorectal cancer,

Read more in Immuno-oncology

GI Oncology

Younger adults present with more advanced esophageal adenocarcinoma,

PDAC: Tumor reduction after neoadjuvant therapy may predict postsurgical survival,

Read more in GI Oncology

Transplant

Caregiver burden of outpatient ASCT for multiple myeloma comparable with inpatient transplant,

Allogeneic transplant leads to durable remissions in T-cell lymphomas,

Read more in Transplant

Translational Research

Will TP53-mutated AML respond to immunotherapy?,

TP53 double hit predicts aggressive myeloma,

Read more in Translational Research

Transfusion Medicine

Hemochromatosis variants may confer 10-fold higher risk of liver cancer,

INR fails to predict bleeding in patients with cirrhosis,

Read more in Transfusion Medicine

Thrombosis

DOACs look safe in elective endoscopic procedures,

Lusutrombopag found safe, effective for severe thrombocytopenia in patients with hepatocellular carcinoma,

Read more in Thrombosis

T Cell Lymphomas

Phase 1 study shows feasibility, safety, efficacy of STAR T cells for ALL,

Duvelisib response rate encouraging in phase 2 PRIMO trial of patients with r/r PTCL,

Read more in T Cell Lymphomas

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Latest Must Reads

Younger adults present with more advanced esophageal adenocarcinoma,

PDAC: Tumor reduction after neoadjuvant therapy may predict postsurgical survival,

Mortality risks rise with age, infections, but not inhibitor status in persons with non-severe hemophilia A,

‘Impressive’ local control with MRI-guided brachytherapy in cervical cancer,

U.S. mothers underestimate role breastfeeding plays in curbing breast cancer,

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