Non-Hodgkin Lymphoma
News
Response to ibrutinib varies by DLBCL subtype
Photo by Larry Young Responses to the BTK inhibitor ibrutinib differ according to a patient’s subtype of diffuse large B-cell lymphoma (DLBCL),...
News
Ibrutinib approved to treat WM in EU
The European Commission has granted marketing authorization for ibrutinib (Imbruvica) to treat Waldenstrom’s macroglobulinemia (WM). The Bruton’s...
News
How B-cell lymphoma evades NK cells
Image by Joshua Strokes Researchers say they have determined how lymphoma cells evade natural killer (NK) cells, and this discovery has revealed...
News
Early progression predicts overall survival in FL
Photo by Rhoda Baer The goal for many cancer patients is to reach the 5-year mark without progression, but a new study suggests 2 years might be a...
News
NICE wants more info on PI3Kδ inhibitor
The UK’s National Institute for Health and Care Excellence (NICE) has opened a consultation on a preliminary draft guidance for the PI3Kδ...
Conference Coverage
Novel mAb targeting CD70 shows activity in TCL
Photo by Linda Bartlett LUGANO—The defucosylated monoclonal antibody (mAb) ARGX-110, which is active against CD70-bearing tumor cells and CD70-...
Conference Coverage
Novel SYK inhibitor shows ‘good early evidence’ of activity
LUGANO—The phase 1, first-in-human study of the novel SYK inhibitor TAK-659 is showing “good early evidence” of antitumor activity in patients...
Conference Coverage
PI3Kδ/γ inhibitor generates rapid responses in CLL
VIENNA—New research indicates that duvelisib, a dual inhibitor of PI3Kδ and PI3Kγ, can generate rapid partial responses in treatment-naïve...
News
Drug can produce durable responses in rel/ref PTCL
anaplastic large cell lymphoma The histone deacetylase inhibitor belinostat can produce durable responses in patients with relapsed/refractory...
Conference Coverage
‘Radically different’ PI3Kδ inhibitor lacks hepatotoxicity
Photo by Larry Young LUGANO—Updated phase 1 results with TGR-1202 suggest this next-generation PI3kδ inhibitor lacks the hepatotoxicity associated...
News
Insecticide can cause NHL, experts say
Photo by John Messina The insecticide gamma-hexachlorocyclohexane (lindane) is carcinogenic, according to experts from the International Agency...