Key clinical point: More than half of hospitalized COVID-19 patients developed at least one superinfection, including 75 cases of ventilator-associated pneumonia and 57 systemic infections. Overall, bacterial infections, age, and the highest Sequential Organ Failure Assessment score were independently associated with ICU mortality or 28-day mortality.
Major finding: The most common pathogens behind cases of ventilator-associated pneumonia were Pseudomonas aeruginosa (34.7%) and Stenotrophomonas maltophilia (18.7%). Bloodstream infections occurred in 16 cases, and fungal infections occurred in 41 cases.
Study details: The data come from a retrospective analysis of prospectively collected data from 92 adults with COVID-19 who were admitted to a single ICU between February 21, 2020, and May 6, 2020.
Disclosures: The study received no outside funding. The researchers had no financial conflicts to disclose.
Source: Signorini L et al. Crit Care Explor. 2021 Jun 11. doi: 10.1097/CCE.0000000000000430.