During follow-up, full transition to osteoporosis occurred in fewer than 1% of the women with a T score of at least -1.00 at baseline, fewer than 5% of those with a T score of -1.01 to -1.49 at baseline, 22% of women with a score of -1.50 to -1.99 at baseline, and in 65% of women with a baseline T score of -2.00 to -2.49.
After adjustment for the covariates of age and continuous bone mineral density, it took an estimated 16 years for 10% of women with a T score of -1.00 or higher at baseline to transition to osteoporosis. The other three subgroups analyzed underwent covariate adjustment for age, body mass index, current estrogen use, any fracture after age 50, current smoking, and oral glucocorticoid use. After adjustment, the average time for 10% of women to transition to osteoporosis was 15.5 years in women following a T score measure of -1.01 to -1.49, 4.5 years in women with a T score of -1.50 to -1.99, and 1.2 years in women with a T score of -2.00 to -2.49.
An additional analysis stratified women by their age at the baseline DXA examination. Even among women aged 85 years, it took an average of nearly 11 years for 10% to develop osteoporosis following a baseline T score of -1.01 to -1.49.
Dr. Gourlay said that she had no disclosures.