Key clinical point: Maternal migraine diagnosis is associated with a higher risk for several childhood cancers in offspring.
Major finding : A significant positive association was observed between maternal migraine and the risk for non-Hodgkin lymphoma (odds ratio [OR] 1.70; 95% CI 1.01-2.86), central nervous system tumors (OR 1.31; 95% CI 1.02-1.68; particularly glioma: OR 1.64; 95% CI 1.12-2.40), neuroblastoma (OR 1.75; 95% CI 1.00-3.08), and osteosarcoma (OR 2.60; 95% CI 1.18-5.76).
Study details: This study included children age < 20 years with cancers (cases) and birth year- and sex-matched (25:1) children without cancers (control individuals).
Disclosures: This study was supported by the US National Institutes of Health. The authors declared no conflicts of interest.
Source: Orimoloye HT et al. Maternal migraine and risk of pediatric cancers. Pediatr Blood Cancer. 2023 (Apr 26). doi: 10.1002/pbc.30385