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Detecting Autoantibodies in Multiple Sclerosis

Evaluating the use of electrochemiluminescence assay

Publish date:: November 20, 2015

The electrochemiluminescence-based assay system expands the currently available toolbox for the detection of autoantibodies in multiple sclerosis (MS) and related diseases, according to a study of cerebrospinal fluid (CSF) from 148 patients with MS and 114 patients with other neurological diseases (OND). Researchers found:

• CSF from patients with MS has higher reactivity toward purified myelin particles vs patients with OND with oligoclonal bands.

• Some of the CSF antibody reactivity is directed against cerebrosides; as determined using liposomes with defined lipid compositions and myelin from ceramide synthase 2 knockout mice.

Citation: Sun X, Bakhti M, Fitzner D, et al. Quantified CSF antibody reactivity against myelin in multiple sclerosis. [Published online ahead of print November 9, 2015]. Ann Clin Transl Neurol. doi: 10.1002/acn3.264.

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