Bilateral deep brain stimulation of the anterior nucleus of the thalamus can help control seizures, but there are reports that suggest it also causes memory problems and depression. When Tröster et al analyzed data from a randomized trial (SANTE), they did find subjective evidence of both adverse events but were unable to confirm the presence of these problems with objective neurobehavioral measures. Nonetheless, they recommend that patients undergoing deep brain stimulation be monitored and undergo neuropsychological assessment for depression and memory problems.
Tröster AI, Meador KJ, Irwin CP, Fisher RS. Memory and mood outcomes after anterior thalamic stimulation for refractory partial epilepsy. Seizure. 2017;45:133-141.
