Patients with MS have a lower increase in serum 25-hyroxyvitamin D (25(OH)D) levels with supplementation, even after accounting for putative confounders, according to a study of 27 female relapsing-remitting MS patients aged 18 to 60 years and 30 healthy controls. Researchers found:
• At baseline, there were no significant differences in 25(OH)D levels or demographics, except a higher body mass index (BMI) in the MS group.
• In a multivariate model accounting for BMI, medication adherence, and oral contraceptive use, MS patients had a 16.7 nmol/l lower increase in 25(OH)D levels compared with controls.
Citation: Bhargava P, Steele SU, Waubant E, et al. Multiple sclerosis patients have a diminished serologic response to vitamin D supplementation compared to healthy controls. [Published online ahead of print August 18, 2015]. Mult Scler. doi:10.1177/1352458515600248.