Key clinical point: Use of progestin-only contraception was associated with greater breast hypertrophy and pain in adolescents with macromastia.
Major finding: Compared to controls, macromastia patients who used progestin-only contraceptives were 500% more likely to report breast pain (odds ratio 4.94); macromastia patients who used progestin-only contraception also had significantly more breast tissue resected during mammaplasty and greater musculoskeletal pain.
Study details: The data come from a retrospective study of 378 macromastia patients aged 12 to 21 years and 378 controls; 5.3% of macromastia patients and 28.0% of controls used progestin-only contraception.
Disclosures: The study was supported in part by the Plastic Surgery Foundation. The researchers had no financial conflicts to disclose.
Source: Nuzzi LC et al. Plast Reconstr Surg Glob Open. 2021 Feb 12. doi: 10.1097/GOX.0000000000003421.