Key clinical point: Low molecular weight heparin (LMWH), vitamin D supplementation, exercise, calcium supplementation, and aspirin reduce the risk for preeclampsia.
Major finding: LMWH (risk ratio [RR] 0.60; 95% CI 0.42-0.87), vitamin D supplementation (RR 0.65; 95% CI 0.45-0.95), exercise (RR 0.68; 95% CI 0.50-0.92), calcium supplementation (RR 0.71; 95% CI 0.62-0.82), and aspirin (RR 0.79; 95% CI 0.72-0.86) were the prophylactic strategies identified to significantly reduce the risk for preeclampsia.
Study details: Findings are from a network meta-analysis of 130 randomized controlled trials that involved 112,916 pregnant women at risk of developing preeclampsia, with preeclampsia being reported in 114 studies including 95,500 women.
Disclosures: This study was supported by the Shuangqing Talent Program Project of Guangdong Provincial People's Hospital, China, among others. The authors declared no conflicts of interest.
Source: Liu YH et al. Prophylactic strategies for preventing pre-eclampsia: A network meta-analysis of randomized controlled trials. Am J Obstet Gynecol. 2022 (Oct 22). Doi: 10.1016/j.ajog.2022.10.014