Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Can a gene expression signature help diagnose endometriosis?

Key clinical point: Doctors may be able diagnose endometriosis by looking at a gene expression signature through analyzing samples from endometrial biopsies, instead of relying on more invasive methods.

Major finding: A biomarker based on five genes that were down-regulated in patients with endometriosis differentiated samples from patients with and without the disease with an area under the receiver operating characteristic curve of approximately 0.99.

Study details: An observational cohort study that included 50 women with endometriosis and 35 controls.

Disclosures: The researchers had no relevant financial disclosures.

Citation:

Aznaurova YB et al. J Minim Invasive Gynecol. 2020 Nov. 27. doi: 10.1016/j.jmig.2020.08.040.