Mild Cognitive Impairment: “Senior Moments” and DSM-5
George T. Grossberg, MD, Saint Louis University
Subjective cognitive impairment (SCI) is a prodrome to mild cognitive impairment (MCI), which is a prodrome to Alzheimer’s disease (AD), although not all patients with MCI convert to AD. Taking a thorough history with the patient and family is the most important part of the dementia workup, which also includes a thorough physical and neurologic exam and neuropsychological assessment. Earliest recognition is possible with biomarkers, but their use is not practical in clinical practice. Depression and anxiety can mimic SCI, which points to the importance of assessing for psychiatric illness. There are no FDA-approved treatments for SCI or MCI, but diet and lifestyle modifications can slow progression.
