In a regression analysis, greater aerobic activity was associated with better cognitive function in subjects who did not carry the ApoE4 high-risk allele and those who carried only one copy: Among those aged 60-69, the mean sMMSE score was 16 in noncarriers and heterozygous carriers who exercised, and 15 in nonexercisers. Among those homozygous for the gene, the mean sMMSE score was 15 in both groups.
A separate analysis looked at subjects aged 70 years and older: In noncarriers, the mean sMMSE was 15.5 in exercisers and 14.5 in nonexercisers. Among heterozygous carriers, the score was 15 in exercisers and 14 in nonexercisers. Among homozygous carriers, the score was 13.5 in exercisers and 11.5 in nonexercisers.
“This study adds to growing evidence that increased levels of physical activity may offer an important primary intervention strategy to attenuate neurocognitive loss. If confirmed in experimental studies, this strategy may have significant public health benefits,” Dr. Obisesan said.