In areas without widespread bacterial resistance to TMP/SMZ, a 3-day course of TMP/SMZ could be considered first-line treatment for uncomplicated UTI in patients without allergies or contraindications. However, in areas where resistance to TMP/SMZ is high, a 7-day course of nitrofurantoin is recommended for uncomplicated cystitis. Resistance patterns can vary from hospital to hospital and even among units in the same hospital;14 therefore, refer to local microbiology labs for “antibiograms” or information regarding resistance patterns.
Dr. Gagliardi reports no financial relationship with any company whose products are mentioned in this article or with manufacturers of competing products.