Evidence-Based Reviews

Can combining triptans with SSRIs or SNRIs cause serotonin syndrome?

Current Psychiatry. 2012 October;11(10):E1-E2

References

1. U.S. Food and Drug Administration. Public health advisory—combined use of 5-hydroxytryptamine receptor agonists (triptans), selective serotonin reuptake inhibitors (SSRIs) or selective serotonin/norepinephrine reuptake inhibitors (SNRIs) may result in life-threatening serotonin syndrome. http://1.usa.gov/U0A0V4. Published July 19, 2006. Accessed September 18, 2012.

2. Kogut SJ. Do triptan antimigraine medications interact with SSRI/SNRI antidepressants? What does your decision support system say? J Manag Care Pharm. 2011;17(7):547-551.

3. Tepper SJ. Serotonin syndrome: SSRIs SNRIs, triptans, and current clinical practice. Headache. 2012;52(2):195-197.

4. Kalaydjian A, Merikangas K. Physical and mental comorbidity of headache in a nationally representative sample of US adults. Psychosom Med. 2008;70(7):773-780.

5. Boyer EW, Shannon M. The serotonin syndrome. N Engl J Med. 2005;352(11):1112-1120.

6. Sternbach H. The serotonin syndrome. Am J Psychiatry. 1991;148(6):705-713.

7. Dunkley EJ, Isbister GK, Sibbritt D, et al. The Hunter Serotonin Toxicity Criteria: simple and accurate diagnostic decision rules for serotonin toxicity. QJM. 2003;96(9):635-642.

8. Ables AZ, Nagubilli R. Prevention recognition, and management of serotonin syndrome. Am Fam Physician. 2010;81(9):1139-1142.

9. Evans RW. The FDA alert on serotonin syndrome with combined use of SSRIs or SNRIs and triptans: an analysis of the 29 case reports. MedGenMed. 2007;9(3):48.-

10. Gillman PK. Triptans serotonin agonists, and serotonin syndrome (serotonin toxicity): a review. Headache. 2010;50(2):264-272.

11. Evans RW, Tepper SJ, Shapiro RE, et al. The FDA alert on serotonin syndrome with use of triptans combined with selective serotonin reuptake inhibitors or selective serotonin-norepinephrine reuptake inhibitors: American Headache Society position paper. Headache. 2010;50(6):1089-1099.

12. Ahn AH, Basbaum AI. Where do triptans act in the treatment of migraine? Pain. 2005;115(1-2):1-4.

13. Pediatric & Neonatal Lexi-Drugs. Hudson, OH: Lexi-Comp, Inc.; 2011.

14. Sclar DA, Robison LM, Castillo LV, et al. Concomitant use of triptan, and SSRI or SNRI after the US Food and Drug Administration alert on serotonin syndrome. Headache. 2012;52(2):198-203.

15. Tepper S, Allen C, Sanders D, et al. Coprescription of triptans with potentially interacting medications: a cohort study involving 240,268 patients. Headache. 2003;43(1):44-48.

Can combining triptans with SSRIs or SNRIs cause serotonin syndrome?

References

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