Key clinical point: Circulating biomarkers for inflammation, abnormal extracellular matrix remodeling, congestion, and myocardial injury were associated with alterations in cardiac structure and function that affected prognosis in patients with rheumatoid arthritis (RA).
Major finding: Left ventricular mass index (LVMi), left atrial volume index (LAVi), and diastolic function (E/e′) were associated with biomarkers of inflammation (tumor necrosis factor receptor superfamily member 11a, bone morphogenetic protein 9, and pentraxin-related protein 3), extracellular matrix remodeling (placental growth factor), congestion (N-terminal probrain natriuretic peptide and adrenomedullin), and myocardial injury (troponin; all P < .05). Higher LVMi (adjusted hazard ratio [aHR] 1.03; P < .001) and E/e ¢ (aHR 1.06; P = .042) were associated with poor prognosis.
Study details: This study included 355 adult patients with RA from the RA Porto cohort .
Disclosures: No information on funding was provided. The authors declared no conflict of interests.
Source: Kobayashi M et al. Front Cardiovasc Med. 2021;8:754784 (Nov 18). Doi: 10.3389/fcvm.2021.754784.