Key clinical point: A serum lipid profile rich in long chain n-3 and n-6 polyunsaturated fatty acids (PUFA) was independently associated with a lower 6-month disease activity in a cohort of patients with early rheumatoid arthritis (RA).
Major finding: At 6 months, the odds of having a 28-joint Disease Activity Score of ≥5.1 was significantly lower in patients in higher tertiles of n-3 PUFA (odds ratio for tertile 3 vs 1 [ORt] 0.49; 95% CI 0.25-0.97) and n-6 PUFA (ORt 0.51; 95% CI 0.28-0.95), with the association being independent of baseline C-reactive protein levels.
Study details: This was a longitudinal cohort study including 669 patients with early RA.
Disclosures: This study was supported by Sorbonne Paris Nord University. The authors declared no conflicts of interest.
Source: Sigaux J et al. Serum fatty acid profiles are associated with disease activity in early rheumatoid arthritis: Results from the ESPOIR cohort. Nutrients. 2022;14(14):2947 (Jul 19). Doi: 10.3390/nu14142947