Key clinical point: A high level of systemic immune-inflammation index (SII) is positively correlated with an increased risk for rheumatoid arthritis (RA).
Major finding: Higher SII score was significantly associated with an increased risk of developing RA, with every unit increase in SII score increasing the risk for RA by approximately 17% (adjusted odds ratio,1.167; P = .020). The risk for RA rapidly increased when SII exceeded the cutoff value of 578.25.
Study details: This study analyzed the data of 37,604 individuals from the US National Health and Nutrition Examination Survey, a population-based cross-sectional survey, of which 2642 had RA.
Disclosures: This study did not receive any funding support. The authors declared no conflicts of interest.
Source: Liu B et al. The association between systemic immune-inflammation index and rheumatoid arthritis: Evidence from NHANES 1999–2018. Arthritis Res Ther . 2023;25:34 (Mar 4). Doi: 10.1186/s13075-023-03018-6