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Genetics and Environment in Gout

Do they play a leading role?

Publish date:: October 12, 2015

A significant component of gout risk may involve complex interplay between genes and environment, according to a study of gout incidence and associated comorbidities in several cohorts of the Framingham Heart Study. Researchers found:

• Significant associations with incident gout were seen for:

◊ Age

◊ Sex

◊ Diabetes

◊ Body mass index (BMI)

◊ Single nucleotide polymorphisms rs1967017, rs13129697, rs2199936, and rs675209

• No BMI by SNP or BMI by serum urate genetic risk interactions were statistically significant.

• Renal disease by rs1106766 was statistically significant.

• Minor alleles of rs1106766 were negatively associated with a risk of incident gout in people without renal disease, but not for those with renal disease.

Citation: Reynolds RJ, Vazquez AI, Srinivasasainagendra V, et al. Serum urate gene associations with incident gout, measured in the Framingham Heart Study, are modified by renal disease and not by body mass index. [Published online ahead of print October 1, 2015]. Rheumatol Int. doi: 10.1007/s00296-015-3364-4.

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