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Gout in Older Adults

Evaluating traditional and genetic factors

Publish date:: January 11, 2016

Traditional and genetic risk factors in middle age may be useful for identifying those at risk of gout in older age, according to a study of adults enrolled in a clinical study between 1987 and 1989 with ongoing follow-up. Researchers found:

• Cumulative incidence of gout from middle age to age 65 was 8.6% in men and 2.5% in women.

• By age 75, cumulative incidence was 11.8% in men and 5.0% in women.

• In middle age, increased adiposity, beer intake, protein intake, smoking status, hypertension, diuretic use, and kidney function were associated with increased gout risk in older age.

• Also in middle age, a 100 µmol/L increase in genetic urate score was associated with a 3.29-fold increased gout risk in older age.

Citation: Burke BT, Kӧttgen A, Law A, et al. Gout in older adults: The Atherosclerosis Risk in Communities study. [Published online ahead of print December 28, 2015]. J Gerontol A Biol Sci Med Sci. doi:10.1093/gerona/glv120.

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