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Periodontal disease management may help to reduce cardiovascular risk in RA
Key clinical point: Atherosclerosis was significantly more prevalent in rheumatoid arthritis patients whose sera showed the presence of antibodies targeting Aggregatibacter actinomycetemcomitans serotype b (anti‐Aa) and/or Aa leukotoxin A (anti-LtxA).
Major finding: Coronary artery calcification scores were significantly higher among rheumatoid arthritis patients with anti‐Aa or anti-LtxA antibodies, compared to individuals without evidence of either antibody (P = .033).
Study details: The data come from a review of 197 adults with rheumatoid arthritis who were assessed for coronary artery calcification, carotid intima media thickness and plaque, and ankle-brachial index via computed tomography, ultrasound, and Doppler ultrasound, respectively; sera assays were used to identify antibodies.
Disclosures: The study was supported by the Jerome L. Greene Foundation and the National Institute of Arthritis and Musculoskeletal and Skin Diseases. The researchers had no financial conflicts to disclose.
Giles JT et al. Arthritis Rheumatol. 2020 Nov 17. doi: 10.1002/art.41572.