Lupus & Connective Tissue Diseases
Conference Coverage
Secukinumab beat placebo for sustained remission of giant cell arteritis after steroid taper
Phase 2 trial results revealed a substantial effect size for secukinumab in extending remission for patients with GCA, but the protocol of...
Conference Coverage
ADVOCATE: Avacopan shows renal benefits in ANCA vasculitis
A subanalysis of renal effects in the phase 3 ADVOCATE trial found that avacopan improved estimated glomerular filtration rate best among patients...
Conference Coverage
Adding rituximab to belimumab offers no help for lupus
The combination of rituximab and belimumab was associated with a longer duration of response, but there was no benefit of belimumab alone for...
Conference Coverage
For EGPA vasculitis, rituximab comparable with cyclophosphamide for inducing remission
A phase 3 trial has found that rituximab is not superior to cyclophosphamide to induce remission in eosinophilic granulomatosis with polyangiitis...
Conference Coverage
mRNA COVID vaccine response found mostly robust in RA, SLE patients
A trial found that immunosuppressed adults with autoimmune disease had a robust antibody response to the mRNA vaccine with no excess adverse...
Conference Coverage
Genotype, need for transfusion predict death in VEXAS syndrome
Among patients with a methionine-to-valine substitution in the UBA1 gene, survival was significantly worse, compared with patients with two other...
Conference Coverage
Lupus patients in remission see more flares with HCQ reduction, discontinuation
It’s clear that more flares occur when patients with lupus in remission or low disease activity stop hydroxychloroquine or reduce its dosing, but...
Conference Coverage
Rituximab improves systemic sclerosis skin, lung symptoms
Patients who took rituximab in the DESIRES trial had better skin scores and lung function at 6 months than did patients who received placebo.
Conference Coverage
Vitamin D and omega-3 supplements reduce autoimmune disease risk
“People who are otherwise healthy and have a family history of autoimmune disease might also consider starting to take these supplements.”
Conference Coverage
Aspirin lowered preeclampsia risk in real-world lupus study
A prospective, single-center study of pregnancies during 1995-2020 showed a reduced risk for preeclampsia among high-risk women with systemic...
Conference Coverage
‘Multimorbidity’ more commonly seen in people with lupus
Two studies find that patients with either systemic or cutaneous disease have higher rates of multiple comorbidities, including those commonly...