Key clinical point: Severe hypoglycemia (SH) is associated with a greater risk for corrected QT (QTc) prolongation in patients with type 2 diabetes mellitus (T2D), especially in younger participants (age <61.9 years), irrespective of other risk factors.
Major finding: Patients with T2D and SH had a higher risk for QTc prolongation (adjusted risk ratio [aRR] 1.66; 95% CI 1.16-2.38), with the risk being higher in patients with 1 (aRR 1.57; 95% CI 1.04-2.39) and ≥2 (aRR 2.01; 95% CI 1.07-3.78) vs no SH episodes and the association remaining significant in younger (aRR 2.63; P = .001) but not in older ( P = .170) patients.
Study details: This prospective cohort study included 8277 patients with T2D from the ACCORD study , of which 324 had ≥1 SH episodes and 517 developed QTc prolongation over a 5-year median follow-up.
Disclosures: The study received no specific funding. GC Fonarow reported being a consultant for various organizations.
Source: Kaze AD et al. Severe hypoglycemia and incidence of QT interval prolongation among adults with type 2 diabetes. J Clin Endocrinol Metab. 2022 (Apr 9). Doi: 10.1210/clinem/dgac195