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Adrenal-permissive genotype linked to poor prognosis in prostate cancer
Men with an adrenal-permissive allele of the gene HSD3B1 are at high risk for worse outcomes from advanced prostate cancer.
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Survival for older AML patients better with HSCT from unrelated donors
“Our findings lend support to our hypothesis that a young [matched unrelated donor] should be the donor of choice when available,” reported the...
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Global project reveals cancer’s genomic playbook
The Pan-Cancer Analysis of Whole Genomes, an international collaboration, reveals the complexity of oncogenesis.
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Lenvatinib/pembrolizumab has good activity in advanced RCC, other solid tumors
Two-thirds of patients with advanced renal cell carcinoma had a clinical response to the TKI/immune checkpoint inhibitor combination.
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High-dose chemo offers survival benefit only for highest-risk breast cancer
Women with 10 or more involved axilliary nodes or triple-negative breast cancer had a 20-year overall survival benefit from high-dose chemotherapy...
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Echoes of SARS mark 2019 novel coronavirus outbreak
One-third of patients hospitalized for 2019 novel coronavirus infection required ICU admission, and six of the 41 (15%) died.
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Adding cannabinoids to opioids doesn’t improve cancer pain control
A systematic review and meta-analysis found no advantage of adjuvant cannabinoids for control of advanced cancer pain.
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Promising early efficacy of venetoclax/navitoclax in r/r acute lymphoblastic leukemia
ORLANDO – Combining the BCL-2 inhibitor venetoclax with low-dose navitoclax produced good response rates in heavily pretreated patients with B-...
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Genomic profiling of AML and MDS yields prognostic clues
ORLANDO – Genome and transcriptome sequencing identified both known mutational combinations and unexpected findings about myeloid disorders.
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High response, survival rates with ponatinib/hCVAD in Ph-positive ALL
ORLANDO – The third-generation tyrosine kinase inhibitor ponatinib is active against Philadelphia chromosome–positive ALL with the T315I mutation...
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QoL good for MGMT-methylated glioblastoma patients with lomustine-temozolide
Adding lomustine to temozolomide did not decrease quality of life for patients, apart from clinically insignificant differences in mental function...
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IORT boosts local control, survival of glioblastoma
A single application of intraoperative radiotherapy followed by standard chemotherapy and maintenance improved outcomes vs. those of historical...
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Chemotherapy better for metastatic breast cancer maintenance than durvalumab
Exploratory analyses showed that patients with triple-negative breast cancer and PD-L1-positive tumors might benefit from durvalumab maintenance...
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PEARL lacks luster in metastatic breast cancer progressing on AIs
SAN ANTONIO – Palbociclib plus endocrine therapy was not superior to capecitabine in patients with HR-positive/HER2-...