Numerous cancer drugs have been studied and found wanting for the treatment of plexiform neuromas and/or malignant peripheral nerve sheath tumors. Among the agents that have failed are sirolimus, sorafenib, erlotinib, sunitinib, ranibizumab, and cediranib. Imatinib has shown mixed results for the treatment of plexiform neuromas; a clinical trial is ongoing.
Disclosures: Dr. Peltonen said she had no relevant financial conflicts.