Key clinical point: Maternal atopic dermatitis (AD) significantly increases the risk for both childhood- and adult-onset AD, and active smoking is the main lifestyle risk factor for adult-onset AD.
Major finding: Compared with non-atopic and atopic control individuals, individuals with a maternal AD family history had a significantly higher risk for childhood-onset (adjusted odds ratio [aOR] 4.36, 95% CI 1.18-16.17; and aOR 32.97, 95% CI 4.03-269.68, respectively) and adult-onset AD (aOR 15.79, 95% CI 1.81-137.74; and aOR 34.15, 95% CI 3.15-370.28, respectively) and active smokers had an increased risk for adult-onset AD (aOR 5.54, 95% CI 1.06-29.01; and aOR 4.03, 95% CI 1.20-13.45, respectively).
Study details: This study analyzed the cross-sectional data of 736 adult individuals with childhood-onset (<18 years) or adult-onset (≥18 years) AD and 76 non-atopic and 91 atopic control individuals without AD.
Disclosures: This study was funded by the Christine Kühne-Center for Allergy Research and Education (CK-CARE), Switzerland. Some authors declared various ties, including employment, with CK-CARE or others.
Source: Maintz L et al. Atopic dermatitis: Correlation of distinct risk factors with age of onset in adulthood compared to childhood. Allergy. 2023 (Mar 22). Doi: 10.1111/all.15721