Patients with atopic dermatitis (AD) have higher odds of depression and suicidality, according to a recent investigation. A systematic review of all published observational studies in databases that analyzed depression in AD was performed. 2 reviewers performed study title and/or abstract review and data abstraction. Pooled meta-analysis was performed by using random-effects weighting. They found:

• Overall, 106 studies met the inclusion criteria; 36 had sufficient data for meta-analysis.
• The prevalence of any depression was higher in persons with vs without AD (20.1% vs 14.8%).
• Similar results were found in sensitivity analyses of studies assessing clinical depression, depressive symptoms, and adults; studies with healthy controls; and studies of low and high study quality.
• AD was associated with significantly higher depression scale scores, parental depression, antidepressant use, and suicidality.