Key clinical point: Involvement of genital, inguinal, and neck regions had higher risk for hidradenitis suppurativa (HS) severity. Comorbidity, longer disease duration, delayed diagnosis, and a higher number of smoking pack-years were other factors associated with disease severity.

Major finding: The most important determinants of disease severity were male sex (odds ratio [OR], 2.211) and involvement of the genital (OR, 3.387), inguinal (OR, 2.253), and neck (OR, 2.197) areas (P less than .001 for all). Patients with obesity (OR, 1.846), comorbidity (OR, 1.879), higher number of smoking pack-years (OR, 1.010), longer disease duration (OR, 1.086), and delayed diagnosis (OR, 1.006) had more severe disease (P less than .001 for all).

Study details: The data come from a multicenter study of 1,221 patients with HS (mean age of disease onset was 26.2 years; 70% were current or former smokers).

Disclosures: No study sponsor was identified. The authors declared no conflicts of interest.