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Changes Serum TWEAK Levels in Conventional vs anti-TNF Treatments

Publish date:: October 21, 2019

Lower serum tumor necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK) levels induce psoriasis and higher levels of TWEAK are observed after treatment, a new study found. Blood samples were collected from 103 patients with moderate or severe chronic plaque psoriasis, with or without arthritis. Psoriasis Area and Severity Index (PASI) scores were calculated, and serum TWEAK levels assessed with TWEK ELISA kit. Researchers found:

Serum TWEAK levels increase significantly and PASI scores decreased significantly after both conventional and anti-TNF treatments.
There was no significant difference between conventional and anti-TNF treatments, between patients with or without comorbid arthritis and between genders.

Citation:

Engin B, et al. Changes in serum TNF-like weak inducer of apoptosis (TWEAK) levels and Psoriasis Area Severity Index (PASI) scores in plaque psoriasis patients treated with conventional versus anti-TNF treatments. [Published online ahead of print September 18, 2019]. Int J Dermatol. doi: 10.1111/ijd.14646.

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