There is a significant association between bullous pemphigoid (BP), a chronic, autoimmune, vesiculobullous disease that frequently occurs in the elderly, and neurological diseases, a recent study found. Researchers performed a comprehensive literature search; case-control and cohort studies that assessed the relationship between BP and neurological diseases were included. 14 studies, with 23,369 BP cases and 128,697 controls, were included in the meta-analysis. They found:

• Patients with BP were significantly more likely to have a stroke, Parkinson disease, dementia, epilepsy, multiple sclerosis, and other neurological diseases, compared to controls.
• Moderate to high heterogeneity were observed for analyses of most neurological diseases, except for Parkinson disease and multiple sclerosis.