Dr. Hans DeVries of the University of Amsterdam examined the closed-loop device for 2 months in 32 adults with type 1 diabetes. They used it overnight; the comparator was their own sensor-augmented pump, which they used during the day while at home.
Again, the closed-loop system improved time spent in target (66.7% vs. 58%); reduced time in hyperglycemia (31.6% vs. 38.5%); reduced time in hypoglycemia (1.6% vs. 3%)); and improved mean glucose (161.6 vs. 167.6 mg/dL). This study also showed a significant reduction in daily insulin (16.2 vs. 18.4 U/kg per day).
The devices are also being tested in a cohort of pregnant women who are enrolled at 8-24 weeks’ gestation. The planned sample size is 18, Dr. Leelarathna said. This is a randomized, crossover study that will use the closed-loop and insulin pump systems for 28 nights with a 2-4 week washout in between. At the end, the women will choose which system to continue with. Some have completed the study, and used the closed-loop system in labor and delivery. Preliminary results look good, Dr. Leelarathna said, although he didn’t release any data.
He had no financial disclosures.